Tie2 and Vascular Stability
The role of Tie2 in maintaining endothelial barrier function.
3 papers
- Angiopoietins and Tie2 in vascular inflammation.Parikh SM. Curr Opin Hematol. 2017
- Endothelial Activation: The Ang/Tie Axis in Sepsis.Leligdowicz A, et al. Front Immunol. 2018
- Tie2 Activation Promotes Protection and Reconstitution of the Endothelial Glycocalyx in Human Sepsis.Drost CC, et al. Thromb Haemost. 2019
Lung Injury and ARDS
Pneumonia, pulmonary vascular leak, acute lung injury and ARDS.
4 papers
- Vasculotide reduces pulmonary hyperpermeability in experimental pneumococcal pneumonia.Gutbier B, et al. Crit Care. 2017
- The Tie2-Agonist Vasculotide Protects Lungs from Pneumonia-Induced Barrier Disruption.Gutbier B, et al. ATS International Conference. 2016
- The Tie2-agonist Vasculotide rescues mice from influenza virus infection.Sugiyama MG, et al. Sci Rep. 2015
- Effects of a synthetic PEG-ylated Tie-2 agonist peptide on endotoxemic lung injury and mortality.David S, et al. Am J Physiol Lung Cell Mol Physiol. 2011
Shock, Trauma and Burns
Vascular leak in severe injury, resuscitation and systemic instability.
4 papers
- Vasculotide, an Angiopoietin-1 Mimetic, Reduces Pulmonary Vascular Leakage and Preserves Microcirculatory Perfusion during Cardiopulmonary Bypass in Rats.Dekker NAM, et al. Br J Anaesth. 2018
- Vasculotide, an Angiopoietin-1 Mimetic, Restores Microcirculatory Perfusion and Microvascular Leakage and Decreases Fluid Resuscitation Requirements in Hemorrhagic Shock.Trieu M, et al. Anesthesiology. 2017
- Mitigating Microvascular Leak during Fluid Resuscitation of Hemorrhagic Shock.Walley KR. Anesthesiology. 2017
- The synthetic Tie2 agonist peptide vasculotide protects against vascular leakage and reduces mortality in murine abdominal sepsis.Kümpers P, et al. Crit Care. 2011
Kidney and Organ Protection
Microvascular dysfunction and organ injury.
3 papers
- The Synthetic Tie2 Agonist Peptide Vasculotide Protects Renal Vascular Barrier Function in Experimental Acute Kidney Injury.Rübig E, et al. Sci Rep. 2016
- Pharmacological Tie2 activation in kidney transplantation.Thamm K, et al. World J Transplant. 2016
- Angiopoietin-1 Mimetic Peptide Promotes Neuroprotection after Stroke in Type 1 Diabetic Rats.Venkat P, et al. Cell Transplant. 2018
Translational Development
From preclinical rationale toward clinical development.
2 papers
- Acceleration of diabetic wound healing by an angiopoietin peptide mimetic.Van Slyke P, et al. Tissue Eng Part A. 2009
- Vasculotide, an Angiopoietin-1 mimetic, reduces acute skin ionizing radiation damage in a preclinical mouse model.Korpela E, et al. BMC Cancer. 2014